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EUCLYD at a glance

Project full title
A European Consortium for Lysosomal Storage Diseases.

Lysosomal Storage Diseases (LSDs) are rare (overall prevalence of 1:5000 to 1:8000), each due to a specific lysosomal enzyme deficiency leading to intracellular storage of a variety of undegraded substrates (sphingolipids, glycosaminoglycans, glycoproteins and glycogen) in different tissues. Among the 40 LSDs presently known, EUCLYD will focus on: Gaucher disease, Pompe disease, Mucopolysaccharidosis VI (MPS VI) and Multiple Sulfatase Deficiency (MSD). The four specific LSDs chosen in this research programme have each unique characteristics, they all differ for the type of stored material and for the involvement of different tissues. This results in different challenges in the treatment of patients and has therefore implications for the choice of specific therapeutic strategies. > [Pages Lysosomal Storage Disorders, Pathogenic mechanisms at the basis of LSDs, Therapeutic approaches for LSDs]

Project mission
The EUCLYD consortium aims at establishing a unique research programme to study Lysosomal Storage Diseases (LSDs) by promoting collaborative scientific interactions between outstanding communities of basic and clinical investigators. To improve human health, scientific discoveries must be translated into practical applications. EUCLYD proposes to study the mechanisms underlying the symptoms of LSDs to then progress towards clinical applications through the development of novel therapeutic approaches with the final goal of moving from “bench to bedside”. > [Pages Project + Aims + Impact]

The EUCLYD consortium brings together six leading European scientists (the Partners) in the field of Lysosomal Storage Diseases (LSDs). The consortium integrates clinical facilities (patients, cells-tissue and DNA samples) with basic research resources (animal models, cell biology and biochemical techniques). This allows proposing an experimental plan in which both aspects are well balanced: easy access to patients and availability of animal models of diseases. > [Page Partners]

EUCLYD is a Collaborative Project (Small or medium-scale focused research project) funded by the European Commission within its Seventh Framework Programme Priority under the thematic area “Natural course and pathophysiology of rare diseases” (FP7-HEALTH-2007-A). Contract number and title: 201678 – A European Consortium for Lysosomal Storage Diseases. Duration: 3 years.